ZNF217

Across TCGA pan-cancer cohorts, ZNF217 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZNF217 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ZNF217 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF217 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

LGG, KIRP, and UCS are the cancer types where ZNF217 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.684	0.940	<.001	53	view →
KIRP	DFS	Tertile	All	0.799	0.922	.008	27	view →
UCS	DFS	Tertile	IV	0.942	0.363	.024	24	view →
LIHC	DFS	Median	All	0.489	0.595	.011	24	view →
MESO	DFS	Tertile	III,IV	0.260	0.406	.008	23	view →
PAAD	DFS	Quartile	All	0.189	0.464	.012	22	view →
SKCM	DFS	Quartile	II,III,IV	0.386	0.226	.009	20	view →
KIRC	DFS	Median	All	0.855	0.731	.007	17	view →
READ	OS	Median	III,IV	0.269	0.685	.003	16	view →
THCA	DFS	Median	All	0.913	0.971	.008	15	view →
LUAD	OS	Median	III,IV	0.619	0.383	.003	13	view →
DLBC	DFS	Median	All	0.629	1.000	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZNF217–LGG (OS)

Open the LGG breakdown →