ZNF208

Across TCGA pan-cancer cohorts, ZNF208 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZNF208 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher ZNF208 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF208 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

ESCA, UCEC, and LIHC are the cancer types where ZNF208 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.312	0.726	<.001	36	view →
UCEC	DFS	Median	All	0.954	0.824	.008	34	view →
LIHC	OS	Median	All	0.331	0.702	<.001	21	view →
LUAD	DFS	Median	II,III,IV	0.780	0.225	.007	19	view →
READ	DFS	Median	II,III,IV	0.082	0.794	<.001	15	view →
OV	DFS	Median	III,IV	0.229	0.534	.014	12	view →
HNSC	DFS	Median	III,IV	0.795	0.550	.019	12	view →
LUSC	DFS	Median	III,IV	1.000	0.331	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ZNF208–ESCA (OS)

Open the ESCA breakdown →