ZNF195

Across TCGA patient cohorts, ZNF195 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF195-associated genes across cancer lineages are PCNA, STAT3_pY705, and EGFR_pY1068. Each is linked with ZNF195 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF195-to-partner and partner-to-ZNF195 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF195-low versus ZNF195-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF195→partner) and Y-score (partner→ZNF195) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.225	+1.836	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.379	-2.247	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.217	-1.584	.006	.005	3	1
UCEC	A-Raf_pS299 →	-0.108	-1.765	.003	.013	3	1
UCEC	ERK2 →	+0.166	+1.807	.006	.024	3	1
UCEC	FASN →	+0.270	+1.415	.029	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by ZNF195 expression — UCEC

Explore this box plot interactively →