ZNF19

Across TCGA patient cohorts, ZNF19 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF19-associated genes across cancer lineages are Notch1, TFRC, and 14-3-3_beta. Each is linked with ZNF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF19-to-partner and partner-to-ZNF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF19-low versus ZNF19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF19→partner) and Y-score (partner→ZNF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.156	+1.594	.003	.042	3	2
UCEC	TFRC →	+0.452	+1.678	.026	.023	3	2
UCEC	14-3-3_beta →	-0.103	-1.973	.007	.029	3	1
UCEC	A-Raf_pS299 →	-0.138	-3.807	.002	<.001	3	1
UCEC	INPP4B →	-0.265	-2.000	.032	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.229	-2.074	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Notch1 by ZNF19 expression — UCEC

Explore this box plot interactively →