ZNF19

Across TCGA pan-cancer cohorts, ZNF19 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF19’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ZNF19 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF19 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KIRP, and KICH are the cancer types where ZNF19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−0.655	<.001	8	view →
KIRP	Male	All	+0.451	<.001	8	view →
KICH	Male	All	−0.648	<.001	7	view →
LIHC	Female	All	+0.247	<.001	7	view →
CHOL	Male	All	+1.134	<.001	5	view →
THCA	Male	II,III,IV	−0.421	.017	4	view →
UCEC	All	All	−0.564	<.001	2	view →
BLCA	Female	III,IV	+0.414	.031	2	view →
COAD	Male	All	+0.207	.005	2	view →
BRCA	Female	All	−0.144	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF19–LUSC

Open the LUSC breakdown →