ZNF185

Across TCGA cell cohorts, ZNF185 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF185-associated genes across cancer lineages are AVP, HMHB1, and OR2T1. Each is linked with ZNF185 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF185-to-partner and partner-to-ZNF185 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by ZNF185-low versus ZNF185-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF185→partner) and Y-score (partner→ZNF185) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	AVP →	+0.045	+4.736	<.001	.009	3	1
SKIN	HMHB1 →	+0.032	+3.700	<.001	.009	3	1
SKIN	OR2T1 →	+0.005	+3.700	<.001	.009	3	1
SKIN	H1-7 →	+0.035	+2.878	.005	.009	3	1
SKIN	OR6C74 →	+0.057	+3.217	<.001	.006	3	1
LARGE_INTESTINE	SLC39A12 →	+0.062	+3.285	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

AVP by ZNF185 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →