ZNF180

Across TCGA patient cohorts, ZNF180 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF180-associated genes across cancer lineages are A-Raf_pS299, GAPDH, and MEK1. Each is linked with ZNF180 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF180-to-partner and partner-to-ZNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ZNF180-low versus ZNF180-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF180→partner) and Y-score (partner→ZNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.096	-1.807	.014	.025	3	2
UCEC	GAPDH →	+0.418	+2.222	.018	.009	3	2
UCEC	MEK1 →	+0.415	+2.906	<.001	.001	3	2
UCEC	Annexin-1 →	+0.549	+2.604	.001	<.001	3	2
UCEC	ASNS →	+0.332	+1.700	.005	.040	3	2
UCEC	ATM →	-0.594	-2.986	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

A-Raf_pS299 by ZNF180 expression — UCEC

Explore this box plot interactively →