ZNF180

Across TCGA cell cohorts, ZNF180 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF180-associated GO terms across cancer lineages are Regulation of chromosome segregation, Chromosome segregation, and Negative regulation of cell cycle phase transition. Each is linked with ZNF180 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZNF180-to-partner and partner-to-ZNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome segregation grouped by ZNF180-low versus ZNF180-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF180→partner) and Y-score (partner→ZNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of chromosome segregation →	+0.085	+0.428	<.001	<.001	3	16
PANCREAS	Chromosome segregation →	+0.090	+0.743	.001	.007	3	16
BONE	Negative regulation of cell cycle phase transition →	+0.090	+0.640	.009	.002	3	15
LARGE_INTESTINE	Regulation of metaphase/anaphase transition of cell cycle →	+0.082	+0.754	<.001	<.001	3	15
LUNG_SCLC	Regulation of microtubule-based process →	+0.080	+0.847	<.001	<.001	3	15
LARGE_INTESTINE	Regulation of sister chromatid segregation →	+0.082	+0.774	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,529 associations by consensus.

Regulation of chromosome segregation by ZNF180 expression — SOFT_TISSUE

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