ZNF180

Across TCGA cell cohorts, ZNF180 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF180-associated genes across cancer lineages are OR5AK2, OR2G6, and SULT1C3. Each is linked with ZNF180 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF180-to-partner and partner-to-ZNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AK2 grouped by ZNF180-low versus ZNF180-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF180→partner) and Y-score (partner→ZNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR5AK2 →	+0.026	+5.169	<.001	.005	3	1
BREAST	OR2G6 →	+0.016	+5.169	<.001	.005	3	1
BREAST	SULT1C3 →	+0.125	+5.169	<.001	.005	3	1
OVARY	OR2D3 →	+0.036	+4.990	<.001	.001	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
LUNG_SCLC	OR9Q2 →	+0.015	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

OR5AK2 by ZNF180 expression — BREAST

Explore this box plot interactively →