ZNF169

Across TCGA patient cohorts, ZNF169 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF169-associated genes across cancer lineages are FoxM1, Caspase-7-cleavedD198, and CDK1. Each is linked with ZNF169 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF169-to-partner and partner-to-ZNF169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ZNF169-low versus ZNF169-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF169→partner) and Y-score (partner→ZNF169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.233	+2.415	.025	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.811	+2.700	<.001	.005	3	2
UCEC	CDK1 →	+0.155	+3.459	.010	.005	3	2
UCEC	A-Raf_pS299 →	-0.150	-2.321	.001	.034	3	1
UCEC	Gab2 →	+0.388	+2.999	.006	.035	3	1
UCEC	GAPDH →	+0.438	+3.169	.042	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FoxM1 by ZNF169 expression — UCEC

Explore this box plot interactively →