ZNF169

Across TCGA pan-cancer cohorts, ZNF169 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF169’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF169 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF169 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where ZNF169 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF169 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.449	<.001	11	view →
LIHC	Female	II,III,IV	+0.307	<.001	7	view →
THCA	All	All	−0.311	<.001	6	view →
CHOL	All	All	+1.252	<.001	5	view →
KICH	Female	All	−0.684	<.001	5	view →
STAD	All	II,III,IV	+0.424	<.001	5	view →
COAD	All	All	+0.273	.003	5	view →
BLCA	All	All	+0.379	.019	4	view →
KIRP	All	IV	+0.482	.039	2	view →
LUAD	All	All	+0.200	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF169–HNSC

Open the HNSC breakdown →