ZNF169

Across TCGA cell cohorts, ZNF169 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF169-associated genes across cancer lineages are DEFB129, AQP2, and PTGDR. Each is linked with ZNF169 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF169-to-partner and partner-to-ZNF169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by ZNF169-low versus ZNF169-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF169→partner) and Y-score (partner→ZNF169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFB129 →	+0.026	+4.437	<.001	.004	3	1
SKIN	AQP2 →	+0.031	+3.938	.001	.005	3	1
SKIN	PTGDR →	+0.012	+3.930	.001	.003	3	1
SKIN	TMEM213 →	+0.045	+3.914	.005	.005	3	1
LARGE_INTESTINE	ACER1 →	+0.075	+3.145	.002	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

DEFB129 by ZNF169 expression — SKIN

Explore this box plot interactively →