ZNF14

Across TCGA patient cohorts, ZNF14 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF14-associated genes across cancer lineages are PDCD4, ASNS, and 4E-BP1_pS65. Each is linked with ZNF14 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF14-to-partner and partner-to-ZNF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ZNF14-low versus ZNF14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF14→partner) and Y-score (partner→ZNF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.545	-2.238	<.001	.001	3	2
UCEC	ASNS →	+0.367	+1.765	.001	.013	3	2
BLCA	4E-BP1_pS65 →	+0.181	+3.169	.039	.019	1	3
UCEC	14-3-3_beta →	-0.076	-2.673	.019	.005	3	1
UCEC	EGFR_pY1068 →	-0.196	-1.459	.016	.012	3	1
UCEC	EGFR →	-0.162	-2.558	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PDCD4 by ZNF14 expression — UCEC

Explore this box plot interactively →