ZNF14

Across TCGA pan-cancer cohorts, ZNF14 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ZNF14’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF14 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF14 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where ZNF14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−1.005	<.001	11	view →
KICH	Male	All	−0.905	<.001	8	view →
LIHC	Female	All	+0.681	<.001	5	view →
CHOL	Male	All	+1.921	<.001	4	view →
LUAD	Female	III,IV	−0.644	.006	4	view →
KIRP	Male	All	−0.476	<.001	2	view →
LUSC	All	III,IV	−0.633	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ZNF14–THCA

Open the THCA breakdown →