ZNF14

Across TCGA cell cohorts, ZNF14 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF14-associated genes across cancer lineages are Niraparib, 123829, and KRAS (G12C) Inhibitor-12. Each is linked with ZNF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF14-to-partner and partner-to-ZNF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by ZNF14-low versus ZNF14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF14→partner) and Y-score (partner→ZNF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.371	+2.868	.027	.022	3	1
LARGE_INTESTINE	123829 →	+0.689	+2.871	.011	.021	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.556	+2.868	.018	.022	3	1
LARGE_INTESTINE	AT-7519 →	+0.995	+2.807	.004	.023	3	1
LARGE_INTESTINE	GSK429286A →	+0.311	+2.874	.036	.021	3	1
LARGE_INTESTINE	WZ3105 →	+0.862	+2.874	.007	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Niraparib by ZNF14 expression — LARGE_INTESTINE

Explore this box plot interactively →