Across TCGA pan-cancer cohorts, ZNF138 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF138 data layer compared with 30 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ZNF138 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF138 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, UCEC, and READ are the cancer types where ZNF138 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.007	0.844	<.001	48	view →
UCEC	DFS	Median	All	1.000	0.610	.003	32	view →
READ	OS	Median	All	0.281	0.830	.006	6	view →
LUAD	OS	Median	All	0.323	0.834	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZNF138 tumor-vs-normal RNA expression · all ZNF138 data types