Across TCGA pan-cancer cohorts, ZNF136 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF136 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF136 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF136 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, THCA, and LUAD are the cancer types where ZNF136 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.300	.002	36	view →
THCA	DFS	Median	All	0.095	0.829	<.001	24	view →
LUAD	OS	Median	II,III,IV	0.141	0.709	<.001	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	II,III,IV	1.000	0.683	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZNF136 tumor-vs-normal RNA expression · all ZNF136 data types