ZNF135

Across TCGA patient cohorts, ZNF135 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF135-associated genes across cancer lineages are p27_pT157, ATM, and ACVRL1. Each is linked with ZNF135 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF135-to-partner and partner-to-ZNF135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by ZNF135-low versus ZNF135-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF135→partner) and Y-score (partner→ZNF135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p27_pT157 →	+0.160	+3.076	<.001	.016	3	3
COAD	ATM →	-0.624	-1.874	<.001	.049	3	3
UCEC	ACVRL1 →	-0.120	-2.980	.016	<.001	3	3
UCEC	PCNA →	+0.242	+3.459	.002	.005	3	3
UCEC	4E-BP1 →	+0.300	+2.730	.002	.003	3	3
COAD	eIF4E →	+0.148	+1.610	.035	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

p27_pT157 by ZNF135 expression — SKCM

Explore this box plot interactively →