ZNF135

Across TCGA pan-cancer cohorts, ZNF135 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZNF135 data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF135 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF135 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

UVM, KIRP, and UCS are the cancer types where ZNF135 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.864	0.360	<.001	108	view →
KIRP	DFS	Tertile	All	0.964	0.823	<.001	75	view →
UCS	DFS	Quartile	III,IV	0.658	0.156	<.001	54	view →
HNSC	DFS	Tertile	III,IV	0.668	0.486	.005	42	view →
MESO	OS	Tertile	All	0.771	0.308	.006	34	view →
ACC	DFS	Median	IV	0.495	0.066	.001	33	view →
LUAD	DFS	Quartile	All	0.827	0.633	.005	29	view →
KIRC	DFS	Quartile	All	0.905	0.726	.002	28	view →
LUSC	DFS	Quartile	III,IV	0.521	0.773	.006	25	view →
SARC	OS	Median	All	0.431	0.738	<.001	21	view →
BRCA	DFS	Quartile	III,IV	0.929	0.777	.009	20	view →
PAAD	DFS	Tertile	All	0.492	0.273	.011	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZNF135–UVM (OS)

Open the UVM breakdown →