ZNF135

Across TCGA cell cohorts, ZNF135 mutation is significantly associated with the RNA expression of many other genes, with 432 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF135-associated genes across cancer lineages are OTOR, PRM2, and MAGEB10. Each is linked with ZNF135 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF135-to-partner and partner-to-ZNF135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by ZNF135-low versus ZNF135-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF135→partner) and Y-score (partner→ZNF135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	PRM2 →	+0.028	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	MAGEB10 →	+0.027	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	MAGEB1 →	+0.658	+3.760	<.001	.008	3	1
LARGE_INTESTINE	SRRD →	+0.866	+3.169	<.001	.006	3	1
LARGE_INTESTINE	GCAT →	+1.312	+3.169	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 432 associations by consensus.

OTOR by ZNF135 expression — URINARY_TRACT

Explore this box plot interactively →