ZNF133

Across TCGA patient cohorts, ZNF133 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF133-associated genes across cancer lineages are PCNA, MEK1, and PKC-b-II_pS660. Each is linked with ZNF133 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF133-to-partner and partner-to-ZNF133 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF133-low versus ZNF133-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF133→partner) and Y-score (partner→ZNF133) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.185	+2.999	.043	.035	3	3
UCEC	MEK1 →	+0.325	+3.169	.036	.018	3	2
UCEC	PKC-b-II_pS660 →	-0.238	-2.000	.042	.030	3	2
UCEC	EGFR_pY1068 →	-0.273	-2.906	.010	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-1.687	.029	.044	3	1
UCEC	mTOR_pS2448 →	-0.166	-2.302	.008	.034	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PCNA by ZNF133 expression — UCEC

Explore this box plot interactively →