ZNF12

Across TCGA cell cohorts, ZNF12 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZNF12-associated genes across cancer lineages are HELT, DUSP21, and ZNF705G. Each is linked with ZNF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF12-to-partner and partner-to-ZNF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELT grouped by ZNF12-low versus ZNF12-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF12→partner) and Y-score (partner→ZNF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HELT →	+0.040	+4.321	<.001	.009	3	1
CNS	DUSP21 →	+0.024	+4.754	<.001	.005	3	1
CNS	ZNF705G →	+0.011	+4.315	<.001	.006	3	1
CNS	IFNA4 →	+0.160	+4.321	<.001	.009	3	1
BREAST	KERA →	+0.047	+4.199	<.001	.007	3	1
BREAST	IFNA2 →	+0.035	+5.754	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

HELT by ZNF12 expression — CNS

Explore this box plot interactively →