ZNF12

Across TCGA cell cohorts, ZNF12 mutation is significantly associated with the mutation status of many other genes, with 2,375 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF12-associated genes across cancer lineages are COG7, CYFIP1, and POLR1A. Each is linked with ZNF12 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF12-to-partner and partner-to-ZNF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COG7 grouped by ZNF12-low versus ZNF12-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF12→partner) and Y-score (partner→ZNF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COG7 →	+3.117	+3.117	.009	.009	1	3
SKIN	CYFIP1 →	+3.117	+3.117	.009	.009	1	3
BLOOD_Leukemia	POLR1A →	+2.894	+4.432	.005	.005	1	3
BLOOD_Leukemia	EXOC5 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	CPAMD8 →	+2.572	+4.129	.009	.009	1	3
CNS	PGAP4 →	+5.199	+5.862	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,375 associations by consensus.

COG7 by ZNF12 expression — SKIN

Explore this box plot interactively →