ZNF114-AS1

Across TCGA pan-cancer cohorts, ZNF114-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated ZNF114-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF114-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF114-AS1 expression acts as an unfavorable survival marker, although some lineages such as THYM and SKCM show a favorable association.

KIRC, HNSC, and LGG are the cancer types where ZNF114-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.542	0.710	<.001	94	view →
HNSC	DFS	Median	All	0.643	0.745	<.001	57	view →
LGG	DFS	Median	All	0.653	0.820	<.001	51	view →
THYM	DFS	Median	II,III,IV	1.000	0.495	<.001	32	view →
MESO	DFS	Median	All	0.276	0.420	.008	21	view →
LIHC	DFS	Tertile	All	0.441	0.571	.007	21	view →
PAAD	DFS	Quartile	All	0.339	0.516	.013	17	view →
ACC	DFS	Median	All	0.222	0.634	.002	17	view →
THCA	DFS	Tertile	IV	0.507	0.848	.009	16	view →
SKCM	OS	Tertile	IV	1.000	0.296	.014	15	view →
UVM	OS	Quartile	III,IV	0.231	0.827	.002	15	view →
DLBC	DFS	Quartile	III,IV	0.074	0.984	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

ZNF114-AS1–KIRC (DFS)

Open the KIRC breakdown →