ZNF114-AS1

Across TCGA pan-cancer cohorts, ZNF114-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ZNF114-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF114-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF114-AS1 is over-expressed in tumor, although a few such as PRAD and STAD show the opposite, repressed pattern.

HNSC, KIRC, and UCEC are the cancer types where ZNF114-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF114-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.404	<.001	12	view →
KIRC	All	II,III,IV	+0.372	<.001	8	view →
UCEC	All	All	+0.479	.006	6	view →
LUAD	All	All	+0.254	.001	6	view →
LUSC	All	II,III,IV	+0.278	.009	4	view →
LIHC	All	II,III,IV	+0.059	.003	3	view →
PRAD	All	All	−0.040	.020	2	view →
STAD	Female	III,IV	−0.280	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ZNF114-AS1–HNSC

Open the HNSC breakdown →