ZNF112

Across TCGA patient cohorts, ZNF112 mutation is significantly associated with the RNA expression of many other genes, with 4,230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF112-associated genes across cancer lineages are RN7SL25P, CENPM, and POLE2. Each is linked with ZNF112 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF112-to-partner and partner-to-ZNF112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL25P grouped by ZNF112-low versus ZNF112-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF112→partner) and Y-score (partner→ZNF112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL25P →	+0.308	+5.925	<.001	.002	3	2
UCEC	CENPM →	+0.510	+1.857	.001	<.001	3	2
UCEC	POLE2 →	+0.513	+2.021	<.001	.001	3	2
UCEC	CDKN3 →	+0.675	+1.868	<.001	<.001	3	2
UCEC	VRK1 →	+0.463	+2.425	.003	.001	3	2
UCEC	RSPO4 →	-1.142	-2.667	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

RN7SL25P by ZNF112 expression — READ

Explore this box plot interactively →