ZNF112

Across TCGA pan-cancer cohorts, ZNF112 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF112’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF112 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF112 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and LIHC are the cancer types where ZNF112 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF112 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.905	<.001	10	view →
UCEC	All	All	−0.705	<.001	6	view →
LIHC	Female	All	+0.433	<.001	6	view →
CHOL	Female	All	+2.153	<.001	5	view →
BLCA	Female	IV	+0.856	.008	4	view →
HNSC	All	III,IV	+0.342	.014	4	view →
KIRC	All	II,III,IV	−0.249	.011	4	view →
KIRP	Male	All	−0.541	<.001	3	view →
LUSC	All	All	+0.350	.001	3	view →
KICH	All	All	−0.362	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF112–THCA

Open the THCA breakdown →