ZNF112

Across TCGA patient cohorts, ZNF112 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF112-associated genes across cancer lineages are Caspase-7-cleavedD198, CDK1, and Cyclin-B1. Each is linked with ZNF112 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF112-to-partner and partner-to-ZNF112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF112-low versus ZNF112-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF112→partner) and Y-score (partner→ZNF112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.853	+2.267	<.001	<.001	3	3
SKCM	CDK1 →	+0.189	+2.321	.029	.035	3	2
UCEC	Cyclin-B1 →	+0.597	+2.058	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.109	-1.986	.022	.008	3	2
UCEC	Rad50 →	-0.220	-1.289	.004	.023	3	2
UCEC	TIGAR →	+0.141	+2.415	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by ZNF112 expression — UCEC

Explore this box plot interactively →