ZNF112

Across TCGA cell cohorts, ZNF112 mutation is significantly associated with the mutation status of many other genes, with 3,299 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF112-associated genes across cancer lineages are THEG, PLXNB3, and CP. Each is linked with ZNF112 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF112-to-partner and partner-to-ZNF112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THEG grouped by ZNF112-low versus ZNF112-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF112→partner) and Y-score (partner→ZNF112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	THEG →	+4.781	+5.536	<.001	<.001	1	4
SKIN	PLXNB3 →	+4.392	+5.357	<.001	<.001	1	4
SKIN	CP →	+4.392	+4.392	.009	.009	1	3
BLOOD_Leukemia	HIVEP2 →	+2.560	+4.364	.002	.002	1	3
BLOOD_Leukemia	CELSR3 →	+2.101	+3.899	.007	.007	1	3
SKIN	ITFG1 →	+5.392	+4.824	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,299 associations by consensus.

THEG by ZNF112 expression — LARGE_INTESTINE

Explore this box plot interactively →