ZMYND15

Across TCGA patient cohorts, ZMYND15 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMYND15-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eEF2. Each is linked with ZMYND15 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZMYND15-to-partner and partner-to-ZMYND15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZMYND15-low versus ZMYND15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMYND15→partner) and Y-score (partner→ZMYND15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.494	+1.720	.016	.025	3	3
UCEC	14-3-3_beta →	-0.109	-3.780	.001	<.001	3	2
UCEC	eEF2 →	+0.375	+2.070	.002	.001	3	2
UCEC	A-Raf_pS299 →	-0.130	-3.321	.001	.009	3	2
UCEC	N-Ras →	-0.110	-3.295	.007	.009	3	2
UCEC	PCNA →	+0.237	+1.906	.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by ZMYND15 expression — UCEC

Explore this box plot interactively →