ZMYND15

Across TCGA pan-cancer cohorts, ZMYND15 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ZMYND15 data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ZMYND15 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZMYND15 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

SKCM, PAAD, and CESC are the cancer types where ZMYND15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.423	0.264	<.001	96	view →
PAAD	DFS	Median	II,III,IV	0.374	0.223	.002	57	view →
CESC	OS	Tertile	III,IV	0.780	0.203	.007	36	view →
READ	DFS	Median	III,IV	0.552	0.215	.008	30	view →
MESO	OS	Tertile	All	0.684	0.464	.010	27	view →
LUAD	OS	Quartile	All	0.866	0.736	.002	27	view →
KIRP	DFS	Quartile	All	0.968	0.836	.005	27	view →
STAD	OS	Tertile	III,IV	0.627	0.398	.015	25	view →
UVM	DFS	Tertile	All	0.622	0.925	.015	23	view →
UCEC	OS	Quartile	All	0.874	0.949	.008	20	view →
PRAD	DFS	Quartile	All	0.804	0.923	.002	18	view →
LGG	DFS	Quartile	All	0.238	0.425	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ZMYND15–SKCM (OS)

Open the SKCM breakdown →