ZMPSTE24

Across TCGA patient cohorts, ZMPSTE24 mutation is significantly associated with the RNA expression of many other genes, with 646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMPSTE24-associated genes across cancer lineages are TIMM9P3, DBIP2, and TCL1B. Each is linked with ZMPSTE24 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMPSTE24-to-partner and partner-to-ZMPSTE24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM9P3 grouped by ZMPSTE24-low versus ZMPSTE24-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMPSTE24→partner) and Y-score (partner→ZMPSTE24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TIMM9P3 →	+0.315	+3.245	.002	.005	3	2
SKCM	DBIP2 →	+0.281	+4.656	<.001	.001	3	2
UCEC	TCL1B →	+0.281	+1.712	.002	.005	3	2
CESC	LINC02559 →	+0.749	+4.020	<.001	.009	3	2
LUSC	MIR6744 →	+0.483	+7.924	<.001	.008	3	2
COAD	SS18L2P1 →	+0.528	+3.373	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 646 associations by consensus.

TIMM9P3 by ZMPSTE24 expression — COAD

Explore this box plot interactively →