ZMPSTE24

Across TCGA pan-cancer cohorts, ZMPSTE24 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZMPSTE24 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZMPSTE24 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZMPSTE24 expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

CESC, KIRC, and KIRP are the cancer types where ZMPSTE24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.667	0.831	.004	78	view →
KIRC	OS	Tertile	All	0.706	0.489	<.001	68	view →
KIRP	DFS	Median	All	0.868	0.963	.002	65	view →
LGG	DFS	Median	All	0.654	0.829	<.001	54	view →
LIHC	OS	Tertile	All	0.588	0.770	<.001	52	view →
UVM	OS	Quartile	All	0.357	0.777	.001	49	view →
ACC	DFS	Median	All	0.560	0.885	.001	42	view →
COAD	OS	Quartile	All	0.943	0.812	.001	41	view →
HNSC	OS	Tertile	II,III,IV	0.564	0.797	.005	28	view →
SCLC	DFS	Median	II,III,IV	0.446	0.738	.002	27	view →
KICH	OS	Tertile	II,III,IV	0.624	1.000	.004	19	view →
CHOL	DFS	Tertile	All	0.811	0.167	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZMPSTE24–CESC (DFS)

Open the CESC breakdown →