ZMAT4

Across TCGA patient cohorts, ZMAT4 mutation is significantly associated with the RNA expression of many other genes, with 2,987 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMAT4-associated genes across cancer lineages are CCT5, SPC25, and SUV39H2. Each is linked with ZMAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMAT4-to-partner and partner-to-ZMAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT5 grouped by ZMAT4-low versus ZMAT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMAT4→partner) and Y-score (partner→ZMAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCT5 →	+0.606	+3.054	<.001	<.001	3	2
UCEC	SPC25 →	+0.623	+2.424	.003	<.001	3	2
UCEC	SUV39H2 →	+0.545	+2.238	.001	.006	3	2
UCEC	CENPH →	+0.639	+2.010	<.001	.001	3	2
UCEC	BUB3 →	+0.460	+2.660	<.001	.005	3	2
UCEC	SKA1 →	+0.758	+2.403	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,987 associations by consensus.

CCT5 by ZMAT4 expression — UCEC

Explore this box plot interactively →