ZMAT4

Across TCGA pan-cancer cohorts, ZMAT4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ZMAT4 data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZMAT4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZMAT4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

ACC, LIHC, and SKCM are the cancer types where ZMAT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Quartile	All	0.262	0.841	.002	44	view →
LIHC	OS	Quartile	II,III,IV	0.486	0.768	<.001	41	view →
SKCM	OS	Median	III,IV	0.509	0.295	.001	36	view →
BLCA	OS	Median	All	0.564	0.651	.008	36	view →
HNSC	DFS	Median	IV	0.468	0.243	.002	34	view →
CESC	DFS	Median	II,III,IV	0.687	0.868	.002	30	view →
KICH	DFS	Median	III,IV	0.277	0.882	.005	14	view →
UCEC	DFS	Quartile	IV	0.709	0.323	.037	8	view →
KIRC	DFS	Tertile	IV	0.554	0.213	.028	8	view →
UCS	OS	Median	IV	0.404	0.752	.013	6	view →
MESO	DFS	Quartile	All	0.742	0.198	.006	6	view →
LUSC	DFS	Median	All	0.373	0.607	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ZMAT4–ACC (OS)

Open the ACC breakdown →