ZMAT4

Across TCGA patient cohorts, ZMAT4 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMAT4-associated genes across cancer lineages are Notch1, Caspase-8, and Bax. Each is linked with ZMAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMAT4-to-partner and partner-to-ZMAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZMAT4-low versus ZMAT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMAT4→partner) and Y-score (partner→ZMAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.196	+3.472	<.001	.002	3	2
UCEC	Caspase-8 →	-0.285	-3.880	.003	<.001	3	2
SKCM	Bax →	-0.233	-3.169	.042	.018	3	2
SKCM	Cyclin-B1 →	+0.449	+2.182	.027	.033	3	2
UCEC	14-3-3_beta →	-0.087	-1.664	.024	.023	3	1
UCEC	EGFR_pY1068 →	-0.282	-2.584	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by ZMAT4 expression — UCEC

Explore this box plot interactively →