Across TCGA pan-cancer cohorts, ZKSCAN5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZKSCAN5 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZKSCAN5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZKSCAN5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, BLCA, and UCEC are the cancer types where ZKSCAN5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.138	0.715	<.001	24	view →
BLCA	DFS	Median	III,IV	0.078	0.489	<.001	18	view →
UCEC	DFS	Median	III,IV	1.000	0.534	.023	16	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	OS	Median	III,IV	0.208	0.791	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZKSCAN5 tumor-vs-normal RNA expression · all ZKSCAN5 data types