Across TCGA pan-cancer cohorts, ZKSCAN5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZKSCAN5’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZKSCAN5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZKSCAN5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
HNSC, THCA, and KIRP are the cancer types where ZKSCAN5 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZKSCAN5 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.