ZKSCAN5

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZKSCAN5 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZKSCAN5-associated genes across cancer lineages are EGFR_pY1068, ACVRL1, and JNK_pT183_Y185. Each is linked with ZKSCAN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN5-to-partner and partner-to-ZKSCAN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN5→partner) and Y-score (partner→ZKSCAN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECEGFR_pY1068 →-0.249-2.169.003.00332
UCECACVRL1 →-0.102-1.514.027.01532
UCECJNK_pT183_Y185 →-0.127-1.501.027.01532
UCECMEK1 →+0.254+1.247.041.04532
SKCMPDCD4 →-0.431-3.321.039.01032
UCECSTAT3_pY705 →-0.297-2.077<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

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