ZKSCAN2-DT

Across TCGA pan-cancer cohorts, ZKSCAN2-DT RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ZKSCAN2-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZKSCAN2-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZKSCAN2-DT expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.

KIRC, COAD, and BLCA are the cancer types where ZKSCAN2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.457	0.710	<.001	98	view →
COAD	DFS	Quartile	All	0.309	0.715	.001	57	view →
BLCA	OS	Median	II,III,IV	0.782	0.651	.001	42	view →
LIHC	OS	Median	II,III,IV	0.280	0.556	<.001	42	view →
UVM	DFS	Tertile	III,IV	0.230	0.855	.001	41	view →
PAAD	OS	Quartile	All	0.656	0.337	<.001	28	view →
THYM	DFS	Median	All	0.873	0.637	.005	25	view →
LUSC	OS	Tertile	All	0.804	0.675	.003	25	view →
PRAD	DFS	Median	All	0.833	0.927	<.001	24	view →
BRCA	OS	Quartile	III,IV	0.984	0.831	.002	23	view →
HNSC	OS	Quartile	III,IV	0.563	0.374	.014	19	view →
READ	OS	Median	II,III,IV	0.737	0.314	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ZKSCAN2-DT–KIRC (DFS)

Open the KIRC breakdown →