ZKSCAN2-DT

Across TCGA pan-cancer cohorts, ZKSCAN2-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZKSCAN2-DT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZKSCAN2-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZKSCAN2-DT is over-expressed in tumor.

COAD, KIRC, and BLCA are the cancer types where ZKSCAN2-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZKSCAN2-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.950	<.001	11	view →
KIRC	All	All	+0.297	<.001	11	view →
BLCA	All	III,IV	+0.735	<.001	9	view →
LIHC	Female	II,III,IV	+0.610	<.001	9	view →
HNSC	Male	IV	+0.495	<.001	8	view →
STAD	All	All	+0.505	<.001	7	view →
CHOL	All	All	+1.901	<.001	5	view →
LUSC	All	All	+0.652	<.001	5	view →
LUAD	All	All	+0.544	<.001	4	view →
BRCA	All	All	+0.279	.004	4	view →
READ	All	All	+0.787	.003	2	view →
PRAD	All	All	+0.407	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZKSCAN2-DT–COAD

Open the COAD breakdown →