ZIM3

Across TCGA patient cohorts, ZIM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,459 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ZIM3-associated GO terms across cancer lineages are Maintenance of cell number, Negative regulation of mRNA metabolic process, and Regulation of double-strand break repair. Each is linked with ZIM3 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZIM3-to-partner and partner-to-ZIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of cell number grouped by ZIM3-low versus ZIM3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIM3→partner) and Y-score (partner→ZIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Maintenance of cell number →	+0.074	+0.211	<.001	.002	3	11
STAD	Negative regulation of mRNA metabolic process →	+0.072	+0.157	<.001	<.001	3	11
STAD	Regulation of double-strand break repair →	+0.071	+0.169	<.001	<.001	3	11
SCLC	Vesicle localization →	+0.066	+0.194	<.001	.001	3	11
STAD	Regulation of mitochondrial gene expression →	+0.073	+0.153	<.001	<.001	3	11
STAD	Regulation of DNA repair →	+0.072	+0.162	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,459 associations by consensus.

Maintenance of cell number by ZIM3 expression — ESCA

Explore this box plot interactively →