ZIM3

Across TCGA pan-cancer cohorts, ZIM3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ZIM3 data layer compared with 5 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZIM3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZIM3 expression acts as an unfavorable survival marker, although some lineages such as CESC and CHOL show a favorable association.

CESC, SKCM, and MESO are the cancer types where ZIM3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.957	0.759	<.001	78	view →
SKCM	OS	Tertile	III,IV	0.520	0.751	<.001	42	view →
MESO	OS	Tertile	II,III,IV	0.245	0.426	.012	39	view →
CHOL	OS	Tertile	All	1.000	0.511	.029	39	view →
UCEC	OS	Quartile	III,IV	0.428	0.643	.021	30	view →
ACC	OS	Tertile	IV	0.402	0.719	.025	27	view →
HNSC	OS	Quartile	All	0.505	0.323	.008	18	view →
ESCA	OS	Quartile	III,IV	0.604	0.309	.022	9	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →
LUAD	OS	Tertile	III,IV	0.285	0.527	.048	9	view →
THCA	DFS	Tertile	IV	0.680	0.962	.023	9	view →
COAD	DFS	Tertile	IV	0.187	0.527	.049	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ZIM3–CESC (OS)

Open the CESC breakdown →