ZIM3

Across TCGA patient cohorts, ZIM3 mutation is significantly associated with the RNA expression of many other genes, with 5,239 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIM3-associated genes across cancer lineages are MAD2L1, MT-RNR2, and RAD51AP1. Each is linked with ZIM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZIM3-to-partner and partner-to-ZIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAD2L1 grouped by ZIM3-low versus ZIM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIM3→partner) and Y-score (partner→ZIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAD2L1 →	+0.727	+1.938	<.001	.001	3	4
SKCM	MT-RNR2 →	-0.622	-1.408	.001	.002	3	4
UCEC	RAD51AP1 →	+0.588	+1.584	.002	.009	3	4
SKCM	COMMD2 →	+0.415	+2.125	.003	<.001	3	4
SKCM	TMEM237 →	+0.390	+1.922	.002	.001	3	4
UCEC	CCNA2 →	+0.829	+2.747	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,239 associations by consensus.

MAD2L1 by ZIM3 expression — UCEC

Explore this box plot interactively →