ZIM3

Across TCGA patient cohorts, ZIM3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIM3-associated genes across cancer lineages are HER2_pY1248, mTOR, and Caspase-7-cleavedD198. Each is linked with ZIM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZIM3-to-partner and partner-to-ZIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2_pY1248 grouped by ZIM3-low versus ZIM3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIM3→partner) and Y-score (partner→ZIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HER2_pY1248 →	-0.332	-2.321	.015	.033	3	3
LUAD	mTOR →	-0.364	-3.321	<.001	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.595	+1.945	.001	.002	3	3
LUAD	4E-BP1 →	+0.507	+2.584	<.001	.011	3	3
UCEC	Rad50 →	-0.149	-1.064	.044	.048	3	3
UCEC	ATM →	-0.516	-1.700	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

HER2_pY1248 by ZIM3 expression — LUAD

Explore this box plot interactively →