ZIM3

Across TCGA cell cohorts, ZIM3 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZIM3-associated genes across cancer lineages are CYP4Z1, DKK4, and S100A7A. Each is linked with ZIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIM3-to-partner and partner-to-ZIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP4Z1 grouped by ZIM3-low versus ZIM3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIM3→partner) and Y-score (partner→ZIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYP4Z1 →	+0.359	+3.531	<.001	.007	3	2
LUNG_NSCLC_LUAD	DKK4 →	+0.139	+2.951	.001	.004	3	1
LUNG_NSCLC_LUAD	S100A7A →	+0.376	+3.696	.001	<.001	3	1
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	SEMG2 →	+0.599	+2.878	<.001	.009	3	1
LARGE_INTESTINE	RASGEF1C →	+0.322	+3.404	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CYP4Z1 by ZIM3 expression — LARGE_INTESTINE

Explore this box plot interactively →