ZIM2

Across TCGA patient cohorts, ZIM2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIM2-associated genes across cancer lineages are ASNS, Caspase-8, and JNK_pT183_Y185. Each is linked with ZIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZIM2-to-partner and partner-to-ZIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZIM2-low versus ZIM2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIM2→partner) and Y-score (partner→ZIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.483	+2.000	.012	.031	3	3
UCEC	Caspase-8 →	-0.227	-2.780	.010	.003	3	3
UCEC	JNK_pT183_Y185 →	-0.167	-1.649	.004	.011	3	2
LUSC	Cyclin-D1 →	-0.173	-1.954	.013	.031	3	2
STAD	FASN →	+0.699	+3.185	<.001	.009	3	2
UCEC	Rad50 →	-0.181	-1.362	.034	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ASNS by ZIM2 expression — SKCM

Explore this box plot interactively →