ZIM2-AS1

Across TCGA pan-cancer cohorts, ZIM2-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZIM2-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ZIM2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZIM2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, HNSC, and SKCM are the cancer types where ZIM2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.839	0.337	<.001	120	view →
HNSC	OS	Median	III,IV	0.746	0.587	.002	72	view →
SKCM	DFS	Median	All	0.686	0.531	<.001	50	view →
LUSC	DFS	Median	All	0.274	0.467	.002	45	view →
ACC	OS	Median	All	0.775	0.973	.002	42	view →
UCS	DFS	Tertile	II,III,IV	0.534	0.122	<.001	40	view →
STAD	DFS	Quartile	All	0.582	0.840	.013	40	view →
LIHC	DFS	Median	All	0.303	0.524	<.001	35	view →
MESO	OS	Median	All	0.658	0.433	.002	34	view →
LUAD	DFS	Median	II,III,IV	0.612	0.473	.010	30	view →
LGG	OS	Median	All	0.751	0.870	<.001	27	view →
CHOL	DFS	Tertile	All	0.861	0.199	.007	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZIM2-AS1–UVM (OS)

Open the UVM breakdown →