ZIM2-AS1

Across TCGA pan-cancer cohorts, ZIM2-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZIM2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZIM2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZIM2-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where ZIM2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZIM2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.191	<.001	12	view →
KICH	Female	All	−0.281	<.001	8	view →
UCEC	All	All	−0.833	<.001	6	view →
THCA	All	II,III,IV	−0.170	<.001	5	view →
STAD	All	All	−0.118	.004	4	view →
LUSC	Female	II,III,IV	−0.192	.002	3	view →
READ	Female	All	−0.154	.031	3	view →
LIHC	All	All	+0.085	.006	2	view →
COAD	All	All	−0.050	.013	2	view →
BLCA	Male	IV	−0.335	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZIM2-AS1–KIRC

Open the KIRC breakdown →