ZIK1

Across TCGA patient cohorts, ZIK1 mutation is significantly associated with the RNA expression of many other genes, with 938 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIK1-associated genes across cancer lineages are MIR3912, DDIT3, and PGBD4P2. Each is linked with ZIK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZIK1-to-partner and partner-to-ZIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3912 grouped by ZIK1-low versus ZIK1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIK1→partner) and Y-score (partner→ZIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR3912 →	+0.350	+3.681	<.001	.005	3	3
UCEC	DDIT3 →	+0.522	+1.828	.001	.002	3	3
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	2
COAD	MS4A13 →	+0.168	+3.546	<.001	.004	3	2
COAD	RPSAP38 →	+0.240	+4.354	<.001	<.001	3	2
COAD	H3P13 →	+0.547	+3.577	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 938 associations by consensus.

MIR3912 by ZIK1 expression — BLCA

Explore this box plot interactively →